The Amazon Mobile Ads SDK should not require any special Proguard configuration to work. Are you receiving errors in the build related to Amazon classes, or are you just not receiving any ads? If you enable logging via AdRegistration.enableLogging(true), do you see any AmazonMobileAds logs in the logcat? Since you're using our ads through Admob, it may be an issue with how Admob accesses our SDK. For instance, some forms of reflection are not recognized by Proguard and could result in Proguard removing classes or methods because it assumes they are never used.